I really don’t know the answer to your question, as I am not a hunter/shooter. I would think if you can shoot slugs out of other full choke guns, there would be no reason the 220 would not handle a slug shell. I am not very well educated on shooting, as my main interest has always been collecting. With this said, I would think the slug shells would have more recoil than a shot shell. Other shooters, am I correct on this? Anyway, a main factory defect in these guns is the weak thin wood where the stock meets the action. I have seen .22 Hornets with cracked stocks. So, it is a good idea for anyone to glass bed their stock before shooting the shotgun/rifle.